Clara Ortega‐de San Luis

The paper shows that innate fear responses to visual looming stimuli in mice can be reduced through repeated exposure and that hippocampal engrams are required for learned fear responses.

The paper visualizes the 3D molecular architecture of engram synapses in the mouse hippocampus using cryoCLEM-guided cryoET to study synaptic plasticity in memory formation.

This study identifies the PHD3-FOXO3 axis as a regulator of the interferon type I response in microglia, which contributes to Alzheimer's disease progression.

The paper investigates how synaptic connectivity between engram cells in the hippocampus and amygdala stores information and supports memory function through PSD-95 mediated plasticity.

This study shows that retroactive interference reduces engram cell reactivation but can be reversed by optogenetic stimulation or environmental cues, indicating adaptive forgetting mechanisms.

The paper shows that immune activation during development can reverse infantile amnesia by reactivating engram cells in mice.