Maura F. O’Neil

This study examines the role of HNF4-cMyc interaction in liver injury and regeneration using a CDE diet model, finding that HNF4 deletion increases injury while cMyc deletion decreases it, with combined deletion leading to a unique HPC activation phenotype.

This study uses a VCD-induced menopause mouse model to show that ovarian loss disrupts hepatic mitochondrial function and lipid homeostasis, increasing susceptibility to diet-induced obesity and steatosis.