Author

Thomas D. Horvath

Baylor College of MedicineORCID 0000-0001-9761-3484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:metabolomics· 3 Assay:metagenomics· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

Abubaker PataniD· 2 shared Andrew D. PattersoniD· 2 shared Anthony MartiniD· 2 shared Antonio Gonzalez· 2 shared Corinn Walker· 2 shared Dionicio Siegel· 2 shared Erin R. ReillyiD· 2 shared Gail L. AckermanniD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Abubaker PatanORCID

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Author profile →

4 papers

Recent·Most cited

Infant gut microbiomes contribute to metabolic states that impact brain function

Firas S. Midani, Do-Hun Lee, Younghye Moon, Maggie N. Seale, Thomas D. Horvath, A. Kyle B. Ardis, Jose O Cantu, Emavieve Coles, Jason D. Pizzini, Duolong Zhu, Sean W. Dooling, Grace J. Ahern, Colleen K. Ardis, Alisha Beckford, Nicole M. Ruggiero, , Heather A. Danhof

The paper shows that infant gut microbiomes influence metabolic states that affect brain function, with interventions restoring normal behavior in mice.

bioRxiv · Mar 10, 2026 · PreprintMicrobiology

Pan-repository analysis reveals a drug-activating function of microbial bile acid conjugation

Vincent Charron‐Lamoureux, Patricia E. Kelly, Simone Zuffa, Abubaker Patan, Marta Sala‐Climent, Corinn Walker, Haoqi Nina Zhao, Shipei Xing, Harsha Gouda, Julius Agongo, Erin R. Reilly, Lina Sallam, Selene F. H. Shore, Subhomitra Ghoshal, Anika K Harpavat, , Pieter C. Dorrestein

The paper identifies microbial bile acid conjugation as a drug-activating function for 5-ASA, revealing its therapeutic relevance through metabolomics analysis.

bioRxiv · Mar 4, 2026 · PreprintBiochemistry

A searchable metadata network graph for microbiome metabolomics

Vincent Charron‐Lamoureux, Shipei Xing, Abubaker Patan, Corinn Walker, Ricardo Almada‐Monter, Yasin El Abiead, Haoqi Nina Zhao, Lucas Patel, Yuhan Weng, Antonio Gonzalez, Gail L. Ackermann, Victoria Deleray, V. Kalai Gandhi, Ipsita Mohanty, Andrés Mauricio Caraballo‐Rodríguez, , Pieter C. Dorrestein

The paper introduces microbiomeMASST, a metadata network graph linking metabolites across datasets, enabling cross-study analysis of microbial metabolites and their biological context.

bioRxiv · Feb 5, 2026 · PreprintBiochemistry

Clostridioides difficile colonization is not mediated by bile salts and utilizes Stickland fermentation of proline in an in vitro model

Xiaoyun Huang, A. E. Johnson, Joshua N. Brehm, Thi Van Thanh Do, Thomas A. Auchtung, Hugh C. McCullough, Armando I. Lerma, Sigmund J. Haidacher, Kathleen M. Hoch, Thomas D. Horvath, Joseph A. Sorg, Anthony M. Haag, Jennifer M. Auchtung

This study shows that C. difficile colonization in an in vitro model is not dependent on bile salts but relies on proline fermentation via Stickland pathway, with context-dependent effects.

mSphere · Jan 16, 2025Peer-reviewedMicrobiology