Author

Sean W. Dooling

Altos LabsORCID 0000-0002-2670-0780Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:behavioral assay· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Mauro Costa‐MattioliiD· 3 shared Lucas Charles ReinekeiD· 2 shared Peter WalteriD· 2 shared A. Kyle B. ArdisiD· 1 shared Adam S. FrostiD· 1 shared Akshara KannaniD· 1 shared Alisha Beckford· 1 shared Benjamin A. YangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Mauro Costa‐MattioliORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Infant gut microbiomes contribute to metabolic states that impact brain function

Firas S. Midani, Do-Hun Lee, Younghye Moon, Maggie N. Seale, Thomas D. Horvath, A. Kyle B. Ardis, Jose O Cantu, Emavieve Coles, Jason D. Pizzini, Duolong Zhu, Sean W. Dooling, Grace J. Ahern, Colleen K. Ardis, Alisha Beckford, Nicole M. Ruggiero, , Heather A. Danhof

The paper shows that infant gut microbiomes influence metabolic states that affect brain function, with interventions restoring normal behavior in mice.

bioRxiv · Mar 10, 2026 · PreprintMicrobiology

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

Lucas Charles Reineke, Ping Zhu, Udit Dalwadi, Sean W. Dooling, Yuwei Liu, I-Ching Wang, Sara K. Young, James T. Okoh, Santosh Kumar Kuncha, Hongyi Zhou, Akshara Kannan, Hyekyung Park, Nicolas A. DeBeaubien, Tristan Ian Croll, D. John Lee, , Mauro Costa‐Mattioli

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience

Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Kristof A. Torkenczy, Lucas Charles Reineke, Sean W. Dooling, Benjamin Henderson, Daniel N. Itzhak, Benjamin A. Yang, Dongze He, R Myers, Peter Walter, Stefka Tyanova, Mauro Costa‐Mattioli

The paper generates a single-cell ISR atlas in a mouse model of persistent ISR activation, identifying cell-type-specific ISR programs and their roles in cognitive decline.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience