Ziwei Liu

This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.

This study introduces bacterial lipoate protein ligases to restore lipoylation and respiration in human and mouse models with lipoylation pathway deficiencies.

The paper reports the structure of SoP450, a self-sufficient cytochrome P450, revealing its dimeric form and electron transfer mechanism.