This study shows that GR activation reorganizes Wnt/LEF1 regulatory circuitry in B-ALL, influencing therapeutic response and resistance through chromatin state changes and gene regulation.

bioRxiv · Sep 24, 2026 · PreprintCancer Biology

Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment

Kashi Raj Bhattarai, Robert J. Mobley, Kelly R. Barnett, Daniel C. J. Ferguson, Baranda S. Hansen, Jonathan D. Diedrich, Brennan P. Bergeron, Satoshi Yoshimura, Wenjian Yang, Kristine R. Crews, Christopher S. Manring, Elias Joseph Jabbour, Elisabeth M. Paietta, Mark Robert Litzow, Steven Mitchell Kornblau, , Daniel Savic

The paper identifies noncoding genetic variants affecting chemotherapy response in childhood ALL by linking them to gene regulatory elements and showing functional impacts on drug sensitivity.

Nature Communications · May 1, 2024Peer-reviewedGenetic & Genomic Medicine

Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures

Kelly R. Barnett, Robert J. Mobley, Jonathan D. Diedrich, Brennan P. Bergeron, Kashi Raj Bhattarai, Alexander C. Monovich, Shilpa Narina, Wenjian Yang, Kristine R. Crews, Christopher S. Manring, Elias Joseph Jabbour, Elisabeth M. Paietta, Mark Robert Litzow, Steven Mitchell Kornblau, Wendy Stock, , Daniel Savic

The paper maps chromatin accessibility in B-ALL subtypes using ATAC-seq, identifies TFs and genetic variants influencing chromatin architecture and gene regulation.

Cell Genomics · Nov 20, 2023Peer-reviewedGenomics