James D. O’Leary

The paper shows that innate fear responses to visual looming stimuli in mice can be reduced through repeated exposure and that hippocampal engrams are required for learned fear responses.

This study investigates how forgetting modulates engram expression using a mouse model, showing that memory can be preserved, retrieved, or forgotten through optogenetic and pharmacological interventions.

This study shows that retroactive interference reduces engram cell reactivation but can be reversed by optogenetic stimulation or environmental cues, indicating adaptive forgetting mechanisms.