Tomás J. Ryan

This study investigates infantile amnesia by testing memory retention in toddlers, finding that early memories persist but become inaccessible, influenced by retrieval mechanisms and prenatal factors.

This study shows that sickness experiences are encoded as brain engrams that, when reactivated, trigger metabolic and immune responses similar to natural sickness.

This study identifies microglia as key regulators of memory accessibility in infancy, showing that their activity modulates infantile amnesia through changes in engram cell interactions and memory persistence.

The paper shows that innate fear responses to visual looming stimuli in mice can be reduced through repeated exposure and that hippocampal engrams are required for learned fear responses.

The paper visualizes the 3D molecular architecture of engram synapses in the mouse hippocampus using cryoCLEM-guided cryoET to study synaptic plasticity in memory formation.

This study shows that engram cells in the auditory cortex have reduced dendritic excitability during memory recall, mediated by increased Ih current.

This study investigates how forgetting modulates engram expression using a mouse model, showing that memory can be preserved, retrieved, or forgotten through optogenetic and pharmacological interventions.

The paper investigates how synaptic connectivity between engram cells in the hippocampus and amygdala stores information and supports memory function through PSD-95 mediated plasticity.

This study shows that retroactive interference reduces engram cell reactivation but can be reversed by optogenetic stimulation or environmental cues, indicating adaptive forgetting mechanisms.

This paper demonstrates a theoretical model using spin-half particles on a topological network to generate brain-like signals and store memory, addressing unresolved theoretical problems in neuroscience.

The paper shows that immune activation during development can reverse infantile amnesia by reactivating engram cells in mice.

This study investigates the role of thalamic axons in goal-directed behavior, showing they encode correct actions and inhibit cortical neurons.

The paper identifies synaptic protein combinations that underlie diverse innate and learned behaviors in mice, showing their role in behavioral repertoire expansion and disease susceptibility.