Mark A. Le Gros

The paper shows that alpha-synuclein phase separation can form Lewy body-like structures without pre-existing seeds, suggesting a new mechanism for neurodegeneration.

The paper decodes acute neuroinflammatory states in mouse microglia by analyzing their 3D cellular architecture and links lipid-endosome reorganization to the mTORC1 pathway.

This paper develops a sparse reconstruction algorithm for soft X-ray tomography to achieve high spatial resolution and whole-cell imaging with reduced radiation dose.

This paper introduces an auto-segmentation pipeline for soft X-ray tomography to enable high-throughput, precise 3D morphometric analysis of yeast cells and organelles.

This paper uses soft X-ray tomography to analyze B.subtilis biofilm structure, showing structural changes in a tasA deletion mutant and the effect of TasA protein addition.