Jian-Hua Chen

This study shows that the nucleus softens during herpesvirus infection due to reduced outward forces and low biomolecular density in the viral replication compartment.

The paper decodes acute neuroinflammatory states in mouse microglia by analyzing their 3D cellular architecture and links lipid-endosome reorganization to the mTORC1 pathway.

This paper develops a sparse reconstruction algorithm for soft X-ray tomography to achieve high spatial resolution and whole-cell imaging with reduced radiation dose.

This paper introduces an auto-segmentation pipeline for soft X-ray tomography to enable high-throughput, precise 3D morphometric analysis of yeast cells and organelles.

This paper uses soft X-ray tomography to analyze B.subtilis biofilm structure, showing structural changes in a tasA deletion mutant and the effect of TasA protein addition.

The paper develops growth-coupled microbial strains for high-yield indigoidine production using iterative engineering and computational evaluation.

The paper uses multimodal imaging and multi-omics techniques to study O. tauri's cellular responses to nitrogen and carbon ratio changes, revealing shifts in lipid and starch metabolism.

The study identifies Ostreococcus tauri as an oleaginous green alga with unique lipid droplet secretion mechanisms resembling pea-pod structures.