Johannes Köster

This study shows short-term T3 treatment improves cardiac function after MI in WT mice, while long-term T3 causes hypertrophy without functional benefit and may worsen function in TR-deficient mice.

The paper shows that thyroid hormone and resmetirom have harmful extrahepatic effects in white adipose tissue that counteract their beneficial effects on the liver in alcohol-associated liver disease in mice.

Datavzrd creates interactive, portable reports from tabular data without programming, enabling easy sharing and visualization across scientific disciplines.

The paper introduces vembrane, a VCF/BCF filtering tool that consolidates and extends filtering functionality using Python expressions.

ProSolo improves variant calling accuracy in single-cell DNA sequencing by addressing amplification bias and errors through a probabilistic model and joint modeling with bulk data.

Microphaser improves haplotyping in cancer samples to create a more accurate neopeptidome for neoantigen prediction.

GGD provides a fast, reproducible way to install standardized data recipes for genomics research, addressing challenges in data collection, transformation, and integration.

This paper introduces a statistical model to improve sensitivity and control false discovery rate in somatic indel discovery by accurately quantifying uncertainties.

The paper introduces a method for full-length de novo viral quasispecies assembly using variation graphs, improving contiguity and accuracy over existing methods.

The paper presents technologies that make computational reproducibility practical by integrating package management, containerization, and workflow systems.

The paper introduces a model to simulate protein complex formation with interaction dependencies, showing that dependencies limit complex sizes and affect perturbation propagation.

This paper introduces a latent variable model to improve sensitivity and control false discovery rate in somatic indel discovery, showing significant improvements in recall for deletions.