Author

Beatrice M. Muriuki

University of Massachusetts Chan Medical SchoolORCID 0000-0001-9824-8706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Carol Lyn Piazza· 3 shared David J. VanceiD· 3 shared Lisa A. CavaciniiD· 3 shared Michael J. RudolphiD· 3 shared Nicholas John MantisiD· 3 shared Clint Vorauer· 2 shared Graham G. WillseyiD· 2 shared Miklós GuttmaniD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

Carol Lyn Piazza

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3 papers

Recent·Most cited

ImmunologyMicrobiology SpectrumPeer-reviewedFeb 14, 2025

A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

David J. Vance, Grace Freeman-Gallant, K. F. McCarthy…·Nicholas John Mantis

This study identifies a type-specific B cell epitope on OspC type A of Borreliella burgdorferi and shows its role in antibody-mediated motility inhibition.

3 citations

mouseproteomics

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ImmunologyThe Journal of ImmunologyPeer-reviewedSep 6, 2024

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

Michael J. Rudolph, Yang Chen, Clint Vorauer…·Nicholas John Mantis

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.

5 citations

humanstructural biology

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ImmunologyInfection and ImmunityPeer-reviewedMar 17, 2024

Single-domain antibodies reveal unique borreliacidal epitopes on the Lyme disease vaccine antigen, Outer surface protein A (OspA)

David J. Vance, Saiful Basir, Carol Lyn Piazza…·Nicholas John Mantis

The paper identifies unique borreliacidal epitopes on OspA using VHHs and evaluates their reactivity across OspA serotypes.

11 citations

protein structureexperimental assay

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