Nicholas John Mantis

Rapid motility arrest of the Lyme disease spirochete, Borrelia burgdorferi, by vaccine-induced OspA antibodies

The paper shows that OspA antibodies rapidly stop B. burgdorferi motility, using single-cell fluorescence microscopy.

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

This paper identifies a conserved epitope on OspA that is broadly protective against multiple Borrelia genospecies, suggesting a basis for a universal Lyme disease vaccine.

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge

This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.

OspA Antibodies Inhibit the In vitro Transmigration of Borreliella burgdorferi

This study shows that OspA antibodies inhibit B. burgdorferi transmigration in vitro, with some antibodies causing bacterial aggregation and others blocking movement without agglutination.

A Salmonella enterica serovar Typhimurium Genome-wide CRISPRi Screen Reveals a Role for Type 1 Fimbriae in Evasion of Antibody-Mediated Agglutination

This study uses a CRISPRi screen to identify genes in Salmonella Typhimurium that affect multicellular aggregate formation in response to Sal4 IgA, revealing a role for Type 1 Fimbriae in evading antibody-mediated agglutination.

Antibody Profiles Elicited by Potent and Subpotent Whole Cell Pertussis Vaccines in Mice

This study identifies distinct antibody profiles in mice vaccinated with potent and subpotent whole cell pertussis vaccines, suggesting a potential serologic surrogate for the intracerebral mouse potency test.

Inter-laboratory harmonization of microsphere immunoassays for SARS-CoV-2 antibody detection in dried blood spots and oral fluids

This study evaluates the interchangeability of dried blood spots and oral fluids for SARS-CoV-2 antibody detection across laboratories using microsphere immunoassays.

Maternal transfer of mRNA LNP-derived, pathogen-specific, monoclonal IgG to suckling mice

This study demonstrates that mRNA-LNPs can deliver pathogen-specific monoclonal IgG into breast milk, enabling transfer of functional antibodies to suckling mice.

A refined human linear B cell epitope map of Outer surface protein C (OspC) from the Lyme disease spirochete, Borreliella burgdorferi

The paper evaluates IgG reactivity to OspC-derived peptides in Lyme disease serum samples, identifying C10 as the most reactive epitope and highlighting complexities in B cell responses.

A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study identifies a type-specific B cell epitope on OspC type A of Borreliella burgdorferi and shows its role in antibody-mediated motility inhibition.

A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication

The paper describes a biparatopic intrabody that protects Vero cells from ricin toxin by targeting two distinct epitopes on the toxin's enzymatic subunit, offering enhanced resistance compared to individual VHHs.

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.