David J. Vance

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

This paper identifies a conserved epitope on OspA that is broadly protective against multiple Borrelia genospecies, suggesting a basis for a universal Lyme disease vaccine.

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge

This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.

A refined human linear B cell epitope map of Outer surface protein C (OspC) from the Lyme disease spirochete, Borreliella burgdorferi

The paper evaluates IgG reactivity to OspC-derived peptides in Lyme disease serum samples, identifying C10 as the most reactive epitope and highlighting complexities in B cell responses.

A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study identifies a type-specific B cell epitope on OspC type A of Borreliella burgdorferi and shows its role in antibody-mediated motility inhibition.

A Biparatopic Intrabody Renders Vero Cells Impervious to Ricin Intoxication

The paper describes a biparatopic intrabody that protects Vero cells from ricin toxin by targeting two distinct epitopes on the toxin's enzymatic subunit, offering enhanced resistance compared to individual VHHs.

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.