Author

Carol Lyn Piazza

New York State Department of Health

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

David J. VanceiD· 4 shared Michael J. RudolphiD· 4 shared Nicholas John MantisiD· 4 shared Grace Freeman-GallantiD· 3 shared Graham G. WillseyiD· 3 shared Lisa A. CavaciniiD· 3 shared Beatrice M. MuriukiiD· 2 shared Clint Vorauer· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

David J. VanceORCID

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4 papers

Recent·Most cited

A Broadly Conserved Protective Epitope on the Lyme Disease Vaccine Antigen, OspA

Graham G. Willsey, Michael J. Rudolph, Carol Lyn Piazza, Yang Chen, Grace Freeman-Gallant, Lisa A. Cavacini, David J. Vance, Nicholas John Mantis

This paper identifies a conserved epitope on OspA that is broadly protective against multiple Borrelia genospecies, suggesting a basis for a universal Lyme disease vaccine.

PLoS Pathogens · Apr 21, 2026Peer-reviewedImmunology

An Fc-silent OspA monoclonal antibody passively protects mice from tick and intradermal Borrelia burgdorferi challenge

Daniel Palmer, Atieh Shemshadian, Katherine Berman, Ariana Nobles, Graham G. Willsey, Carol Lyn Piazza, Grace Freeman-Gallant, Michael J. Rudolph, Jeffrey S. Bourgeois, Linden Hu, David J. Vance, Nicholas John Mantis

This study shows that an Fc-silent variant of the monoclonal antibody LA-2 provides equivalent passive protection against Borrelia burgdorferi in mice, suggesting its protective mechanism is independent of complement.

PLoS ONE · Mar 12, 2026Peer-reviewedImmunology

A type-specific B cell epitope at the apex of Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

David J. Vance, Grace Freeman-Gallant, K. F. McCarthy, Carol Lyn Piazza, Yang Chen, Clint Vorauer, Beatrice M. Muriuki, Michael J. Rudolph, Lisa A. Cavacini, Miklós Guttman, Nicholas John Mantis

This study identifies a type-specific B cell epitope on OspC type A of Borreliella burgdorferi and shows its role in antibody-mediated motility inhibition.

Microbiology Spectrum · Feb 14, 2025Peer-reviewedImmunology

Structure of a human monoclonal antibody in complex with Outer surface protein C (OspC) of the Lyme disease spirochete, Borreliella burgdorferi

Michael J. Rudolph, Yang Chen, Clint Vorauer, David J. Vance, Carol Lyn Piazza, Graham G. Willsey, Kathleen McCarthy, Beatrice M. Muriuki, Lisa A. Cavacini, Miklós Guttman, Nicholas John Mantis

This study determines the structure of a human monoclonal antibody in complex with OspC from Borreliella burgdorferi, revealing its epitope and interaction mechanism.

The Journal of Immunology · Sep 6, 2024Peer-reviewedImmunology