Daniel Y. Zhu

OSK factors rejuvenate aged RPE cells by activating a Tet2-independent oxidative resilience pathway through GSTA4, restoring vision and reversing age-related degeneration.

The paper develops AutoTransOP, an autoencoder framework to translate omics signatures across species and contexts, outperforming existing methods in identifying predictive molecular features.

Spateo provides a framework for spatiotemporal modeling of single-cell spatial transcriptomics data to study cell-cell interactions and organ development in 3D space.

This paper identifies the AANAT1 gene as the genetic basis for the speck mutation in Drosophila melanogaster, showing that mutations in AANAT1 lead to the speck phenotype through altered dopamine metabolism.

The paper investigates how microtubule plus-end density affects growth rates, providing experimental evidence for feedback mechanisms in microtubule dynamics.