Harnessing cGAS-STING signaling to counteract the genotoxic-immune nexus in tauopathy
Himanshi Singh, Sazzad Khan, Jianfeng Xiao, Nicole Nguyen, Asmita Das, Daniel L. Johnson, Francesca Fang-Liao, Sally Ann Frautschy, Michael P. McDonald, Tayebeh Pourmotabbed, Mohammad Moshahid Khan
This study identifies a cGAS-STING signaling loop driving neuroinflammation and tau pathology in tauopathies, showing its disruption can alleviate disease symptoms.
bioRxiv · Sep 27, 2025 · PreprintNeuroscience