Mohammad Moshahid Khan

The paper analyzes regulator activity across mouse PFF Parkinson disease models and human PD data, identifying shared transcriptional programs in dopaminergic identity, protein homeostasis, and inflammation.

This study shows that DYT1 mutations in mice disrupt gut microbiome composition and gut-brain axis dynamics, linking intestinal dysfunction to motor impairments.

This study identifies the integrated stress response (ISR) activation and DNA damage-driven immune dysregulation as key drivers of ATO-induced delayed neurotoxicity and cognitive deficits.

This study identifies a cGAS-STING signaling loop driving neuroinflammation and tau pathology in tauopathies, showing its disruption can alleviate disease symptoms.

The paper shows that UBTF1 and SL1 cooperate to enable RNA Polymerase I promoter recognition in rDNA, and this cooperation is disrupted in UBTF-E210K neuroregression syndrome.