Valeria A. Risso

The paper identifies a prevalent transcription error in influenza hemagglutinin mRNA that leads to a phenotypic mutation reducing binding of broadly neutralizing antibodies.

This study examines the error landscape of hemagglutinin-encoding RNA in influenza, showing that mutations from high-frequency errors are preferentially selected during evolution.

This study compares the substrate scope of a modern and ancestral family-1 glycosidase, finding the ancestral enzyme more efficient with large aglycon-containing flavonoid glycosides.

This paper describes an engineered archaeal PTP with enhanced thermostability and unique biochemical properties, revealing insights into enzyme evolution and biotechnological potential.

The paper shows that virus propagation can occur through low-level host protein variants caused by gene-expression errors, using bacteriophage T7 and thioredoxin as a model.

The paper demonstrates that AI tools can efficiently identify high-fitness protein variants and predict antibody evasion patterns using limited experimental data.

The paper identifies heme protection by polypeptides as a mechanism enhancing catalytic efficiency in ancestral proteins, suggesting it may have driven the evolution of enzymes.