Boguslawa Sadowski

This study examines natural cardiovascular aging in non-human primates, finding histological and molecular changes associated with aging, including fibrosis, inflammation, and atherosclerosis.

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

This study shows that continuous myelin synthesis is necessary for maintaining white matter integrity, as preventing new myelin formation in adult mice leads to myelin degradation and neurological disease.

This study shows that TET1-mediated DNA hydroxy-methylation is essential for adult remyelination, with loss of function leading to impaired myelin repair in aged mice.