Wiebke Möbius

Red fluorescent labeling of myelin by membrane-targeted tdTomato in transgenic mouse lines

The paper develops transgenic mouse lines with red fluorescent labeling of myelin, enabling structural and functional imaging compatible with green spectral sensors.

A myelinic channel system for motor-driven organelle transport

The paper identifies the myelinic channel system as a pathway for microtubule-dependent organelle transport in oligodendrocytes, showing its role in maintaining axonal integrity through neuronal activity and motor proteins.

Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS mice

This study shows that mutant SOD1 aggregates in myelinic nanochannels and accelerates ALS progression in mice, highlighting the role of myelin channel integrity in disease.

Fatty acid binding protein-8 (FABP8/PMP2) reveals molecular heterogeneity of myelin sheaths in the human CNS

This paper identifies FABP8/PMP2 as a defining feature of human and old-world monkey CNS myelin, revealing molecular heterogeneity in myelin sheaths and its role in cholesterol enrichment.

Natural aging drives a subclinical cardiovascular phenotype in a non-human primate

This study examines natural cardiovascular aging in non-human primates, finding histological and molecular changes associated with aging, including fibrosis, inflammation, and atherosclerosis.

Detection of alpha synuclein seeding activity in tear fluid in patients with Parkinson's disease

This study detects alpha-synuclein seeding activity in tear fluid from Parkinson's disease patients using aSynSAA, showing higher activity in PD compared to controls and prion disease.

Tau oligomer heterogeneity and associated protein profile in slowly versus rapidly progressive Alzheimer's disease

This study compares Tau oligomer properties in slowly and rapidly progressive Alzheimer's disease, finding distinct biochemical and proteomic profiles associated with different clinical progression rates.

Tether-mediated extraction of myelinoid bodies by microglia and astrocytes can maintain myelin integrity

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

This study uses MINFLUX nanoscopy to map the nanoscale organization of proteins at inner hair cell synapses in mice, revealing nanocluster-based structures in active zones and postsynaptic densities.

Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development

This study identifies CRH-expressing OPCs that prevent premature differentiation following CNS injury and in early development, highlighting CRHR1's role in oligodendrogenesis.

Transcriptional dynamics of the oligodendrocyte lineageand its regulation by the brain erythropoietin system

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

This study shows that AP2 complex is essential for myelin sheath biogenesis and homeostasis, with loss of AP2 causing hypomyelination and hypermyelination in different developmental stages.

Molecular and structural remodeling of stress granules in slowly and rapidly progressive Alzheimer's disease

This study characterizes stress granule structural and molecular changes in Alzheimer's disease subtypes using multi-omics approaches, revealing distinct features in rapidly progressive AD.

Developmental axon diameter growth of central nervous system axons does not depend on ensheathment or myelination by oligodendrocytes

This study shows that CNS axon diameter growth does not require oligodendrocyte ensheathment or myelination, contrasting with PNS findings.

Axon demyelination and degeneration in a zebrafishspastizin model of hereditary spastic paraplegia

This study investigates the effects of spastizin mutations in zebrafish, showing axon demyelination and degeneration in M-cells, leading to impaired locomotion.

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

The paper challenges the view that axonal degeneration in MS results from immune-mediated damage by proposing that myelin itself increases axonal degeneration risk under inflammatory conditions.

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses

This study investigates the role of piccolino in cochlear inner hair cell synapses, finding it contributes to active zone organization and is essential for normal synaptic transmission.

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

The paper compares myelin proteome and oligodendrocyte transcriptome profiles between humans and mice, finding both conservation and divergence in specific proteins and genes.

Stage-specific control of oligodendrocyte survival and morphogenesis by TDP-43

This study shows that TDP-43 loss affects oligodendrocyte survival and myelination differently at various stages of maturation, leading to morphological defects and neurological impairments.

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

This study shows that CMTM5 deficiency in oligodendrocytes leads to progressive axonopathy, suggesting its role in maintaining axonal integrity rather than myelin formation.

Myelin lipids as nervous system energy reserves

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells

This study compares the release and effects of alpha-synuclein, Tau, and huntingtin in neuronal cells, showing similar release pathways and impacts on neuronal activity and inflammation.

Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development

The paper investigates myelin structural changes during development in mice and zebrafish, finding that myelin degeneration is resolved by microglia, while sheath retractions occur independently.

Oligodendrocytes support axonal transport and maintenance via exosome secretion

This study shows that oligodendrocyte exosome secretion supports axonal transport and neuronal viability, and its impairment leads to axonal degeneration in mouse mutants.

A role of oligodendrocytes in information processing independent of conduction velocity

This study shows that oligodendrocytes contribute to sustained stimulus perception in complex auditory tasks, beyond their role in increasing axonal conduction velocity.

White matter integrity requires continuous myelin synthesis at the inner tongue

This study shows that continuous myelin synthesis is necessary for maintaining white matter integrity, as preventing new myelin formation in adult mice leads to myelin degradation and neurological disease.

Macromolecular and electrical coupling between inner hair cells in the rodent cochlea

The paper shows that 30% of inner hair cells in the rodent cochlea form electrochemical mini-syncytia through membrane fusion, enhancing sound encoding sensitivity and reliability.