Torben Ruhwedel

Tether-mediated extraction of myelinoid bodies by microglia and astrocytes can maintain myelin integrity

The paper shows that microglia and astrocytes extract myelinoid bodies via tethers, preserving myelin sheath integrity through tension-driven scission and fusion.

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

This study uses MINFLUX nanoscopy to map the nanoscale organization of proteins at inner hair cell synapses in mice, revealing nanocluster-based structures in active zones and postsynaptic densities.

Neuropeptide CRH prevents premature differentiation of OPCs following CNS injury and in early postnatal development

This study identifies CRH-expressing OPCs that prevent premature differentiation following CNS injury and in early development, highlighting CRHR1's role in oligodendrogenesis.

Axon demyelination and degeneration in a zebrafishspastizin model of hereditary spastic paraplegia

This study investigates the effects of spastizin mutations in zebrafish, showing axon demyelination and degeneration in M-cells, leading to impaired locomotion.

Oligodendrocytes and neurons contribute to amyloid-β deposition in Alzheimer's disease

The paper shows oligodendrocytes contribute to amyloid-β plaques in Alzheimer's disease, but neurons are required for plaque formation.

Potassium regulates axon-oligodendrocyte signaling and metabolic coupling in white matter

This study shows that oligodendrocytes use potassium signaling to regulate axonal metabolism and maintain axonal health through metabolic coupling.

Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer's disease

This study shows that ageing-related myelin dysfunction drives amyloid-beta deposition in Alzheimer's disease mouse models, suggesting myelin integrity as an upstream risk factor.

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

This study shows that CMTM5 deficiency in oligodendrocytes leads to progressive axonopathy, suggesting its role in maintaining axonal integrity rather than myelin formation.

Myelin lipids as nervous system energy reserves

The paper shows that myelin acts as an energy reserve in the brain under glucose deprivation, supporting oligodendrocytes and axons through fatty acid oxidation.

Myelin biogenesis is associated with pathological ultrastructure that is resolved by microglia during development

The paper investigates myelin structural changes during development in mice and zebrafish, finding that myelin degeneration is resolved by microglia, while sheath retractions occur independently.

A role of oligodendrocytes in information processing independent of conduction velocity

This study shows that oligodendrocytes contribute to sustained stimulus perception in complex auditory tasks, beyond their role in increasing axonal conduction velocity.

White matter integrity requires continuous myelin synthesis at the inner tongue

This study shows that continuous myelin synthesis is necessary for maintaining white matter integrity, as preventing new myelin formation in adult mice leads to myelin degradation and neurological disease.