M. Agustina Frechou

The paper introduces TrUDI, a three-photon microscopy system that improves imaging depth in the mouse brain to ~2 mm with enhanced fluorescence detection.

This study shows that adult neurogenesis in mice enhances spatial information encoding in the hippocampus during novel context exposure.

This study shows that aged mice have impaired spatial representations in the hippocampal dentate gyrus for novel environments, but these improve with repeated exposure, while hyperexcitability does not disrupt familiar environments.

The paper shows that initial seizures in mice increase mossy cell-granule cell synaptic transmission via BDNF-dependent LTP, which worsens seizures and suggests a mechanism for epileptogenesis.