Pablo E. Castillo

GluN2D-containing NMDA receptors support dentate granule cell excitability, synaptic plasticity, and memory

This study investigates the role of GluN2D-containing NMDA receptors in dentate granule cells, showing their importance in excitability, synaptic plasticity, and spatial memory.

Astrocytic Nonsense-mediated mRNA decay regulates calcium signaling to support synapse function and influence anxiety-like behavior

This study shows that NMD in astrocytes regulates calcium signaling and synapse function, affecting anxiety-like behavior in mice.

Individuals with intellectual disability have an increased burden of de novo variants in cis-regulatory elements of glutamatergic neurons.

Developmental disruption of Mef2c in Medial Ganglionic Eminence-derived cortical inhibitory interneurons impairs cellular and circuit function

This study shows that loss of MEF2C in embryonic cortical GABAergic interneurons reduces their number and maturation, leading to altered brain function and neurodevelopmental disorder-like behaviors.

Nr4a2 blocks oAbeta-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APPSw,Ind mouse

This study shows that Nr4a2 activation prevents oAβ-induced synaptic dysfunction and memory deficits in AD mouse models.

BETA-HYDROXYBUTYRATE COUNTERACTS THE DELETERIOUS EFFECTS OF A SATURATED HIGH-FAT DIET ON SYNAPTIC AMPA RECEPTORS AND COGNITIVE PERFORMANCE

This study shows that beta-hydroxybutyrate (BHB) improves AMPA receptor levels and cognitive performance in mice exposed to a high-fat diet.

Dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal function

This study shows that dopamine D2 receptors in mossy cells reduce excitatory transmission and are essential for hippocampal function, with implications for anxiety and epilepsy.

Phosphorylation alters FMRP granules and determines their transport or protein synthesis abilities

This study shows that phosphorylation of FMRP at S499 alters granule structure and function, affecting transport and translation in neurons.

Real-time imaging of Arc/Arg3.1 transcription ex vivo reveals input-specific immediate early gene dynamics

This study uses real-time imaging to show that Arc/Arg3.1 transcription in neurons varies based on the type of synaptic input, revealing distinct dynamics for medial and lateral perforant path activation.

Activation of extrasynaptic kainate receptors drives hilar mossy cell activity

This study shows that mossy cells in the hippocampus express functional extrasynaptic kainate receptors that can drive their activity when glutamate levels increase.

Heterosynaptic NMDA Receptor Plasticity in Hippocampal Dentate Granule Cells

This study investigates NMDA receptor plasticity at different synapses in hippocampal dentate granule cells, finding that MPP-GC synapses exhibit homosynaptic LTP while inducing heterosynaptic LTP at LPP-GC synapses.

BDNF induces its own release to mediate presynaptic plasticity

This paper shows BDNF induces its own release to mediate long-lasting increase in neurotransmitter release through TrkB and calcium-dependent mechanisms.

Donor-derived vasculature is required to support neocortical cell grafts after stroke

This study shows that including vascular cells with neural precursor cells improves graft survival and vascularization after stroke.

Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1

This study shows that Iba1 deficiency in mice leads to microglial dysfunction, reduced synaptic development, and behavioral impairments.

Cycles of transcription and local translation support molecular long-term memory in the hippocampus

The paper investigates how transcription and translation cycles of the IEG Arc support long-term memory in the hippocampus by maintaining mRNA supply to dendrites.

Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures

This study identifies adenosine/A2A receptor retrograde signaling as a mechanism for presynaptic long-term potentiation and seizure promotion in hippocampal circuits.

Activity-dependent LTP in the dentate gyrus promotes epileptic seizures

The paper shows that initial seizures in mice increase mossy cell-granule cell synaptic transmission via BDNF-dependent LTP, which worsens seizures and suggests a mechanism for epileptogenesis.

Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

Retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 pyramidal cell synapse

The paper investigates retrograde suppression of post-tetanic potentiation at the mossy fiber-CA3 synapse using acute mouse hippocampal slices, finding Ca2+-dependent regulation.

Presynaptic FMRP and local protein synthesis support structural and functional plasticity of glutamatergic axon terminals

This study shows that presynaptic FMRP and local protein synthesis regulate structural and functional plasticity in hippocampal mossy fiber-CA3 synapses.

CB1 receptor-mediated inhibitory LTD triggers presynaptic remodeling via protein synthesis and ubiquitination

This study shows that CB1 receptor-mediated inhibitory LTD involves protein synthesis and ubiquitination to cause presynaptic structural changes that reduce GABA release.