Shiny Shengzhen Guo

This study shows that transmembrane domain interactions in integrin β1-subunit are essential for proper folding and surface expression, with mutations disrupting these interactions causing functional impairments and embryonic lethality.

The paper identifies USP12/46 deubiquitinases that prevent ESCRT-mediated lysosomal degradation of β1 integrin by removing ubiquitin from its cytoplasmic tail in early endosomes.