Peng Xu

Limited O-specific polysaccharide (OSP)-specific functional antibody responses in young children with Shigella infection in Bangladesh

This study examines antibody responses to Shigella in Bangladeshi children, finding that younger children have less effective functional antibody responses against OSP and proteins, correlating with disease severity.

A Multi-Omics Study of Cognitive Resilience to Alzheimer's Disease

The paper develops a multi-omics cohort of prefrontal cortex data from cognitively normal older adults to identify molecular signatures of cognitive resilience to Alzheimer's disease.

Discovery of ARQ-501 as a potent PafA inhibitor that elevates KatG levels to potentiate isoniazid in mycobacteria

The paper identifies ARQ-501 as a PafA inhibitor that increases KatG levels, enhancing isoniazid efficacy against tuberculosis.

In situ architecture of plasmodesmata suggests mechanisms controlling intercellular exchange

The paper uses cryo-electron tomography to study plasmodesmata structure in Physcomitrium patens, revealing callose's role in shaping channels and identifying MCTP protein assemblies.

NuMA promotes constitutive heterochromatin compaction by stabilizing linker histone H1 on chromatin

This study identifies NuMA's role in stabilizing linker histone H1 on chromatin to promote heterochromatin compaction and maintain epigenetic repression.

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins

Mass spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: Comparison to IHC and FISH

This study compares mass spectrometry-based Her2 quantitation to IHC and FISH in gastroesophageal tumors, finding high concordance and improved specificity.