Cell BiologybioRxivPreprint
Disrupted endothelial cell-cell dynamics in ALK1 and SMAD4 deficiency drive arteriovenous malformations
David T A Hardman, Olya Oppenheim, Wolfgang Giese…·Miguel O. Bernabéu
This study shows that ALK1 and SMAD4 deficiencies disrupt endothelial cell interactions, leading to arteriovenous malformations through distinct biomechanical mechanisms.
DOI 10.1101/2025.11.26.690643