Wolfgang Giese

This paper investigates how matrix stiffness and shear stress jointly influence endothelial gene expression and angiogenic activation thresholds using transcriptomics.

This study identifies gene-specific mechanisms of AVM formation in endothelial cells with SMAD4 or ALK1 loss-of-function, showing distinct molecular and cellular pathways leading to different vascular malformations.

This study shows that ALK1 and SMAD4 deficiencies disrupt endothelial cell interactions, leading to arteriovenous malformations through distinct biomechanical mechanisms.

Polarity-JaM is an open-source image analysis tool for quantifying cell polarity, junctions, and morphology using deep learning and provides statistical analysis features.

The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.

The paper shows that WASp regulates endothelial cell migration directionality in zebrafish, leading to proper vascular patterning and preventing vascular malformations.

The paper analyzes how spatial factors affect signaling cascades in cells, showing that membrane-cytosolic interface dynamics and cell geometry significantly influence signal transduction.