Olya Oppenheim

Gene-specific endothelial programs drive AVM pathogenesis in SMAD4 and ALK1 loss-of-function

This study identifies gene-specific mechanisms of AVM formation in endothelial cells with SMAD4 or ALK1 loss-of-function, showing distinct molecular and cellular pathways leading to different vascular malformations.

Disrupted endothelial cell-cell dynamics in ALK1 and SMAD4 deficiency drive arteriovenous malformations

This study shows that ALK1 and SMAD4 deficiencies disrupt endothelial cell interactions, leading to arteriovenous malformations through distinct biomechanical mechanisms.

Polarity-JaM: An image analysis toolbox for cell polarity, junction and morphology quantification

Polarity-JaM is an open-source image analysis tool for quantifying cell polarity, junctions, and morphology using deep learning and provides statistical analysis features.

Reconstructing stochastic cell population trajectories reveals regulators and heterogeneity of endothelial flow-migration coupling driving vascular remodelling

The paper develops a computational model to analyze EC migration during vascular remodelling, finding that directional migration is driven by dual force fields and mediated by Cdc42 with cell population heterogeneity.