Miguel O. Bernabéu

This study shows that Kindlin-1 loss in cutaneous squamous cell carcinoma disrupts ECM-vascular organization, leading to hypoxia and tumor progression.

This study examines how ovarian hormones affect cerebral and retinal blood flow across the menstrual cycle, finding that estrogen increases blood flow in both the brain and eye, while progesterone affects the brain alone.

This study uses a computational model to show that in tumours, oxygen and drug concentration overlap is reduced compared to healthy tissue, affecting drug efficacy.

This study shows that systemic FAK inhibition reduces immunosuppressive macrophages in glioblastoma by blocking monocyte trafficking, enhancing T cell activity and improving survival in a mouse model.

This study shows that ALK1 and SMAD4 deficiencies disrupt endothelial cell interactions, leading to arteriovenous malformations through distinct biomechanical mechanisms.

This study shows PIEZO2 channels are critical for coronary artery development, as their absence causes vessel malformations and cardiac issues in mice.

The paper shows that WASp regulates endothelial cell migration directionality in zebrafish, leading to proper vascular patterning and preventing vascular malformations.

This study identifies intrinsic endothelial dysfunction as a cause of cerebral small vessel disease in a normotensive rat model, independent of hypertension.

The paper shows that competition between biochemical and mechanical cues regulates endothelial cell polarity, driving vascular morphogenesis through tension shifts.

The paper investigates how erythrocyte dynamics influence vascular remodelling in developing networks, finding that RBC depletion correlates with vessel regression and that plasma skimming drives this process.

PolNet quantifies endothelial cell polarity and blood flow in vascular networks using image analysis and computational fluid dynamics.