Cancer BiologybioRxivPreprint
Defined cellular reprogramming of androgen receptor-active prostate cancer to neuroendocrine prostate cancer
Shan Li, Kai Song, Huiyun Sun…·John K. Lee
This study reprograms AR-active prostate cancer to NEPC using ASCL1 and NeuroD1, revealing their role in silencing AR and altering chromatin structure.