Colorectal cancer relies on an immunosuppressive cellular topography and genomic adaptations for establishing brain metastases
Anuja Sathe, Mengrui Zhang, Xiangqi Bai, Ji In Kang, Rithika S. Meka, Huiyun Sun, Susan M. Grimes, Aparajita Khan, Mingen Liu, Andrew S. Luksik, Michael K. Lim, Claudia Katharina Petritsch, Christopher Mitchell Jackson, Hannes S. Vogel, Jeanne Shen, , Hanlee P. Ji
This study identifies the immunosuppressive cellular and genomic features of colorectal cancer brain metastases and their mechanisms of adaptation.
bioRxiv · Nov 14, 2025 · PreprintCancer Biology