Post-Translational Modifications Remodel Proteome-Wide Ligandability
Weichao Li, Qijia Wei, Manuel A. Llanos, Clara Gathmann, Paolo Governa, Tzu-Yuan Chiu, Jacob M. Wozniak, Appaso M. Jadhav, Matthew Holcomb, Jacob B. Cravatt, Ashok R. Dongré, Mia L. Huang, Stefano Forli, Christopher G. Parker
The paper identifies how post-translational modifications affect protein ligandability by profiling PTM-dependent small-molecule interactions in human cells.
Nature Chemical Biology · May 5, 2026Peer-reviewedBiochemistry