Christopher G. Parker

This paper identifies a direct interaction between SLC15A4 and LAMTOR1 that is required for endolysosomal TLR-mediated mTOR signaling and inflammatory cytokine production.

The paper identifies how post-translational modifications affect protein ligandability by profiling PTM-dependent small-molecule interactions in human cells.

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

The paper introduces AgnoTACs, bifunctional molecules that enable proteome-wide discovery of degradable proteins, identifying over 50 previously untargeted proteins.

This study identifies DCA as a microbiota-derived bile acid that activates STING and enhances antitumor immunity via NK cell activation.

This study shows that trifluoroacetate reduces plasma lipids and atherosclerosis in mice by activating PPAR-alpha, but also highlights its environmental and clinical relevance.