Matthew Holcomb

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium

This study shows that inhibiting SagA, a peptidoglycan hydrolase, increases vancomycin susceptibility in VREfm through both genetic and pharmacological approaches.

Post-Translational Modifications Remodel Proteome-Wide Ligandability

The paper identifies how post-translational modifications affect protein ligandability by profiling PTM-dependent small-molecule interactions in human cells.

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling

This study shows that IXA4 inhibits SLC33A1, causing ER hyperoxidation and activating IRE1/XBP1s signaling, which reduces viability of KEAP1-deficient lung cancer cells.

Design principles of the common Gly-X6-Gly membrane protein building block

The paper uses protein design to investigate the structural principles of common antiparallel transmembrane motifs, revealing how sequence patterns stabilize membrane protein architectures.

An mRNA Display Approach for Covalent Targeting of a Staphylococcus aureus Virulence Factor

The paper develops fluorescent probes for FphB, a Staphylococcus aureus enzyme, using mRNA display with a genetically encoded electrophile, achieving nanomolar selectivity.

IP6 and PF74 affect HIV-1 Capsid Stability through Modulation of Hexamer-Hexamer Tilt Angle Preference

This study uses atomistic simulations to show how IP6 and PF74 modulate HIV-1 capsid stability by altering hexamer-hexamer tilt angles, revealing distinct effects on structural flexibility.