Satoko Komatsu‐Hirota

The paper shows that KEAP1 retention in p62 bodies and NRF2 activation cause liver damage when autophagy is impaired, and that blocking p62-KEAP1 interactions reduces this damage.

This study shows that loss of SPNS1 in the nervous system causes dysmyelination and white matter dysplasia in mice, suggesting a role for SPNS1 mutations in human congenital white matter disorders.