Author

Jacob A. Steele

St. Jude Children's Research HospitalORCID 0000-0001-9924-2226Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Burgess B. FreemaniD· 2 shared John B. EastoniD· 2 shared Jon P. ConnellyiD· 2 shared Shondra M. Pruett‐MilleriD· 2 shared Allister J. LoughraniD· 1 shared Andrew Cortes· 1 shared Andrew Jackson MurphyiD· 1 shared Andrew M. DavidoffiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

Burgess B. FreemanORCID

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2 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedSep 17, 2025

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity

Shivendra Vikram Singh, Jie Fang, Hongjian Jin…·Jun J.J. Yang

This study shows that targeting RBM39 with indisulam promotes natural killer cell activity and eradicates neuroblastoma regardless of cellular state plasticity.

14 citationstop 3%

humanmouse

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Cancer BiologyNature CommunicationsPeer-reviewedFeb 28, 2025

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

Min Pan, Yinwen Zhang, William C. Wright…·Paul Geeleher

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

7 citations

humangenetic perturbation / CRISPR

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