Author

Aurélia C. Balestra

University of PennsylvaniaORCID 0000-0001-9934-6404Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Boris StriepeniD· 2 shared Abigail M. DanielsiD· 1 shared Allison Ballandras-ColasiD· 1 shared Anitha Ndayiragije· 1 shared Bethan A. WallbankiD· 1 shared Bettina BöttcheriD· 1 shared Bingjie Xu· 1 shared Christian KlotziD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

Boris StriepenORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintOct 15, 2026

Cryptosporidium sex employs a complex male fertilization apparatus that is required for continued infection

Aurélia C. Balestra, Maria I. Merolle, Tim Bergner…·Boris Striepen

This study identifies a complex male fertilization apparatus in Cryptosporidium, essential for infection, and shows that disrupting HAP2 prevents fertilization and clears infection.

DOI 10.64898/2026.10.13.757955

experimental assay

MicrobiologyNature MicrobiologyPeer-reviewedMay 13, 2026

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance

Gracyn Y. Buenconsejo, Sebastian Shaw, Rui Xiao…·Boris Striepen

The paper identifies genomic heterogeneity at the NDH2 locus in Cryptosporidium species that contributes to clofazimine resistance through adaptive recombination.

2 citationstop 1%

humanmouse

Molecular BiologyPLoS PathogensPeer-reviewedMay 20, 2024

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus

Wim Pascal Burmeister, Laetitia Boutin, Aurélia C. Balestra…·Frédéric Iseni

The paper presents the 3.8 Å cryo-EM structure of the VACV DNA polymerase holoenzyme and shows its structural similarity to MPXV, with transient E9-D4 interactions and conformational flexibility.

3 citations

virusprotein structure