Author

Frédéric Iseni

Institut de Biologie StructuraleORCID 0000-0003-3909-9688Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

Laetitia Boutin· 2 shared Alicia MasiD· 1 shared Alı́ AlejoiD· 1 shared Allison Ballandras-ColasiD· 1 shared Aurélia C. BalestraiD· 1 shared Bettina BöttcheriD· 1 shared Christian KraftiD· 1 shared Clemens GrimmiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Laetitia Boutin

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintFeb 20, 2025

In vitro and in vivo Antiviral Activity of the Acyclic Nucleoside Phosphonate Prodrug LAVR-289 against Poxvirus and African Swine Fever Virus Replication

Elie Marcheteau, Estelle Mosca, Gaelle Frénois-Veyrat…·Franck Gallardo

This study evaluates LAVR-289, a nucleoside analogue, showing antiviral activity against poxviruses and ASFV in vitro and in vivo with no toxicity.

DOI 10.1101/2025.02.20.634468

mouseexperimental assay

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Molecular BiologyPLoS PathogensPeer-reviewedMay 20, 2024

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus

Wim Pascal Burmeister, Laetitia Boutin, Aurélia C. Balestra…·Frédéric Iseni

The paper presents the 3.8 Å cryo-EM structure of the VACV DNA polymerase holoenzyme and shows its structural similarity to MPXV, with transient E9-D4 interactions and conformational flexibility.

3 citations

virusprotein structure

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