Author

Laetitia Boutin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Research Focus:variant effect prediction· 1 Organism:virus· 1

Frequent Co-Authors

Frédéric IseniiD· 2 shared Alicia MasiD· 1 shared Alı́ AlejoiD· 1 shared Allison Ballandras-ColasiD· 1 shared Aurélia C. BalestraiD· 1 shared Bettina BöttcheriD· 1 shared Christian KraftiD· 1 shared Clemens GrimmiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Frédéric IseniORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

In vitro and in vivo Antiviral Activity of the Acyclic Nucleoside Phosphonate Prodrug LAVR-289 against Poxvirus and African Swine Fever Virus Replication

Elie Marcheteau, Estelle Mosca, Gaelle Frénois-Veyrat, Sandrine Kappler‐Gratias, Laetitia Boutin, Sokunthea Top, Thomas Mathieu, Cyril Colas, Patrick Favetta, Tony Garnier, Peggy Barbe, Mathilde Keck, Daniel Gillet, Alicia Mas, Alı́ Alejo, , Franck Gallardo

This study evaluates LAVR-289, a nucleoside analogue, showing antiviral activity against poxviruses and ASFV in vitro and in vivo with no toxicity.

bioRxiv · Feb 20, 2025 · PreprintMicrobiology

Structure and flexibility of the DNA polymerase holoenzyme of vaccinia virus

Wim Pascal Burmeister, Laetitia Boutin, Aurélia C. Balestra, Henri Gröger, Allison Ballandras-Colas, Stephanie Hutin, Christian Kraft, Clemens Grimm, Bettina Böttcher, Utz Fischer, Nicolas Tarbouriech, Frédéric Iseni

The paper presents the 3.8 Å cryo-EM structure of the VACV DNA polymerase holoenzyme and shows its structural similarity to MPXV, with transient E9-D4 interactions and conformational flexibility.

PLoS Pathogens · May 20, 2024Peer-reviewedMolecular Biology