Thomas Sommer

This study uses single-molecule imaging to show that Hrd1 forms stable tetramers in the ER, revealing a conserved hydrophobic motif critical for dislocation.

This study reveals that autophagy selectively clears the endoplasmic reticulum during inflammation-induced muscle atrophy, challenging the classical view of atrophy as a uniform degradation process.

The paper uses multi-omic profiling to study early regulatory changes in dexamethasone-induced muscle atrophy in C2C12 cells, identifying mitochondrial gene expression and alternative splicing alterations.

The paper identifies branch- and length-specific ubiquitin chain interactors in humans and yeast, revealing how different Ub architectures are decoded by proteins.