Sonia Malaiya

A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan

Reprocessing nine human brain datasets (2,157,582 cells, 156 donors, GW6 to adulthood) under one marker-based taxonomy yields 35 replicable cell types with cell type-specific timing of adult-like maturation.

The cellular diversity of human cerebrospinal fluid following intraventricular hemorrhage revealed by single-nucleus RNA sequencing

This study uses single-nucleus RNA sequencing to analyze CSF leukocytes after IVH, identifying distinct immune cell states and signaling networks involved in inflammation.

Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to Huntington’s disease mutations

This study uses single-nucleus RNA-seq to analyze striatal cell types in a Huntington’s disease mouse model, revealing dysregulated gene expression and cell identity loss across multiple cell types.