Sridevi Venkatesan

The paper shows that spaced theta-burst stimulation enhances synaptic potentiation in the prefrontal cortex of socially isolated mice.

The paper characterizes a Grin1Q536R/+ mouse model carrying a GRIN1 variant, showing age- and sex-dependent behavioral and physiological changes linked to GRIN1-NDD.

Reprocessing nine human brain datasets (2,157,582 cells, 156 donors, GW6 to adulthood) under one marker-based taxonomy yields 35 replicable cell types with cell type-specific timing of adult-like maturation.

The paper shows that a GluN1 variant causes NMDAR dysfunction in mice, leading to seizures, and demonstrates that boosting negative feedback can treat them.

The paper develops a cell type-agnostic model to predict developmental age from transcriptomes, achieving high accuracy across human brain datasets and organoids.

The paper shows enhanced nicotinic signaling in prefrontal cortex of AD models, which can be amplified by nicotinic receptor modulation without altering kinetics.

This study investigates the effects of the GRIN1 Y647S variant in mice, showing that β-hydroxybutyrate reduces convulsions associated with the variant.

This study shows that xanomeline restores age-related nicotinic signaling deficits in mouse prefrontal cortex by enhancing muscarinic receptor pathways and nicotinic receptor availability.

This study shows that deficits in extrasynaptic NMDARs caused by Grin1 disruption can be rescued in adult mice through genetic intervention.

The paper identifies Chrna5-expressing super-responder subplate neurons using transgenic mice and single-cell transcriptomics, revealing unique lynx prototoxin gene expression and potential therapeutic targets for attention disorders.

This study shows that Chrna5 enables rapid and resilient cholinergic responses in prefrontal cortex, crucial for attention, and identifies NS9283 as a potential treatment for Chrna5 disruption.