Patricia R. Nano

Reprocessing nine human brain datasets (2,157,582 cells, 156 donors, GW6 to adulthood) under one marker-based taxonomy yields 35 replicable cell types with cell type-specific timing of adult-like maturation.

This study shows that glutamatergic neuron-tumor synapses influence glioblastoma cell states by modulating radial glia plasticity and transcriptional programs.

The paper identifies YBX1 as a key transcription factor in shaping human prefrontal cortex molecular identity through CRISPR activation screens and organoid experiments.

The paper maps clonal hierarchies in glioblastoma using lineage-resolved single-cell data, revealing multiple non-redundant progenitors and identifying cell type-specific therapeutic targets.

The paper uses a human organoid tumor transplantation system to study glioblastoma-microenvironment interactions, identifying PTPRZ1 as a key mediator of intercellular communication.

This study shows thalamic NRXN1 signaling promotes human cortical upper-layer neurogenesis by interacting with outer radial glia.

The paper integrates seven single-cell transcriptomic datasets to generate 225 meta-modules, identifying key gene networks involved in human cortical cell subtype specification and validating their roles in neurodevelopment.

The paper identifies the pentose phosphate pathway's role in regulating radial glia cell fate during human cortical development using metabolic assays and genetic manipulations.

This study identifies a neurovascular progenitor cell type in glioblastoma that links distinct malignant lineages and influences tumor composition and survival.

This study shows that human-specific SRGAP2B/C paralogs drive neotenic microglia maturation and influence synaptic development in human brains.