Luciano Custo Greig

This study identifies Bcl11b's role in regulating subcerebral projection neuron axon development through both cell-autonomous and non-cell-autonomous mechanisms involving Cdh13.

BEAM generates two genetically distinct cell populations for mosaic analysis by using sparse recombinase activation to label cells with green or red fluorescent protein.

The paper identifies topographic principles in the corpus callosum that guide axon connectivity between brain hemispheres through symmetric adhesion molecule levels and co-fasciculation.

This study shows that the ASD/ID gene Bcl11a is essential for precise axonal targeting and circuit formation in CPN, with its deletion causing behavioral and molecular disruptions in mice.