Cheryl Brandenburg

This study identifies a cerebellar-midbrain pathway that selectively gates social vocalizations and demonstrates that targeted neuromodulation can restore vocal behavior without improving motor coordination.

The paper shows that Purkinje cell loss in aged mice occurs in parasagittal stripes and is linked to motor dysfunction, with similar patterns observed in human postmortem samples.

The paper uses stereo-tracking to study Purkinje cell development and identifies a new subcellular structure called axon bubbles.

The paper identifies topographic principles in the corpus callosum that guide axon connectivity between brain hemispheres through symmetric adhesion molecule levels and co-fasciculation.

The paper develops a high-throughput workflow to assess Cas9 editing precision and identifies a novel Cas9 fusion that improves knockin performance in vivo.

The paper examines region-specific changes in perineuronal net expression in postmortem autism brain tissue, finding reduced PNN density around parvalbumin neurons in the globus pallidus.

The paper identifies a parvalbumin-positive subtype of Purkinje neurons with distinct firing properties and shows that ion channel differences contribute to firing diversity.