Rudolf Grosschedl

This study shows EBF1 regulates the blood-thymus barrier by modulating Claudin-5 expression in thymic endothelial cells, affecting early thymic progenitor influx.

The paper shows lineage-determining transcription factors position enhancers and promoters to enable multi-enhancer regulation of oncogenes in lymphoma and T-cell leukemia.

The paper shows that Sema7A and Sema4D heterodimerization is essential for membrane targeting and neocortical wiring, with a mutation in Sema4D causing epilepsy.

The paper shows that indirect and direct striatal neurons intermix through active migration, with Ebf1 mutation disrupting this process and affecting striatal architecture.