Andrew G. Newman

IgLON5 autoimmune antibodies activate Tau via neuronal hyperactivity

This study shows that IgLON5 autoantibodies cause neuronal hyperactivity and Tau pathology by clustering cell surface proteins, linking them to neurodegeneration.

Tau modulates nuclear integrity, chromatin, and cholesterol synthesis genes via the nuclear envelope

This study shows that increased somatodendritic Tau interacts with nuclear envelope proteins, causing nuclear damage and altering gene expression related to AD and tauopathies.

Nurr1 orchestrates claustrum development and functionality

This study identifies Nurr1 as a critical transcription factor for claustrum development and function, showing its role in neuronal positioning and behavior regulation.

Glial Reactivity and Cognitive Decline Follow Chronic Heterochromatin Loss in Neurons

The paper shows chronic heterochromatin loss in neurons leads to ERV de-repression, inflammation, and cognitive decline in mice.

Neurod2/6 transcription factors control basal progenitor differentiation and sequential production of neocortical cell subtypes

This study shows that Neurod2/6 regulate basal progenitor differentiation and sequential production of neocortical cell subtypes by inhibiting Tbr2-dependent genetic programs.

Ire1α-Regulated mRNA Translation Rate Controls the Identity and Polarity of Upper Layer Cortical Neurons

The paper shows that Ire1α regulates mRNA translation rates, which control the identity and polarity of upper layer cortical neurons through eIF4A1 and eEF-2.

Sema7A and Sema4D Heterodimerization is Essential for Membrane Targeting and Neocortical Wiring

The paper shows that Sema7A and Sema4D heterodimerization is essential for membrane targeting and neocortical wiring, with a mutation in Sema4D causing epilepsy.

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptors

This study shows HERV-K(HML-2) RNA activates TLR8 and Tlr7, causing neurodegeneration in mice and correlating with AD in humans.

On the relation of phase separation and Hi-C maps to epigenetics

The paper investigates how phase separation and Hi-C maps relate to epigenetics by examining HP1 and H3K9me2/3 in heterochromatin domains.