Fabien Ménardy

Functional abnormalities in the cerebello-thalamic pathways in an animal model of dystonia

A mouse model of DYT25 dystonia with a Gnal mutation shows altered cerebello-thalamic plasticity, which can be modulated by theta-burst stimulation to reduce dystonia severity.

Cerebellar stimulations prevent Levodopa-induced dyskinesia in mice and normalize brain activity

The paper shows that cerebellar stimulations reduce or prevent levodopa-induced dyskinesia in mice by normalizing brain activity and reversing neuronal plasticity.

Vestibular CCK neurons drive motion-induced malaise

The paper identifies CCK-expressing vestibular neurons as key drivers of motion-induced malaise and shows their role in inducing conditioned taste aversion through parabrachial nucleus activation.

Defined neuronal populations drive fatal phenotype in Leigh Syndrome

The paper identifies two genetically-defined neuronal populations in Ndufs4KO mice that drive distinct pathological features of Leigh Syndrome.

Active intermixing of indirect and direct neurons builds the striatal mosaic

The paper shows that indirect and direct striatal neurons intermix through active migration, with Ebf1 mutation disrupting this process and affecting striatal architecture.