The paper constructs a comprehensive mass spectral library for human thyroid tissues to improve the detection of malignant nodules through proteomic analysis.

bioRxiv · May 27, 2021 · PreprintSystems Biology

DPHL: A pan-human protein mass spectrometry library for robust biomarker discovery using Data-Independent Acquisition and Parallel Reaction Monitoring

Tiansheng Zhu, Yi Zhu, Yue Xuan, Huanhuan Gao, Xue Cai, Sander R. Piersma, Thang V. Pham, Tim Schelfhorst, Richard R. de Haas, Irene V. Bijnsdorp, Rui Sun, Liang Yue, Guan Ruan, Qiushi Zhang, Mo Hu, , Tiannan Guo

The paper introduces DPHL, a pan-human protein mass spectrometry library built using DIA and PRM, and demonstrates its utility in identifying differentially expressed proteins in prostate cancer and DLBCL.

Genomics Proteomics & Bioinformatics · Apr 1, 2020Peer-reviewedBioinformatics

Phenotype Prediction using a Tensor Representation and Deep Learning from Data Independent Acquisition Mass Spectrometry

Fangfei Zhang, Shaoyang Yu, Lirong Wu, Zelin Zang, Xiao Yi, Jiang Zhu, Cong Lu, Ping Sun, Yaoting Sun, Sathiyamoorthy Selvarajan, Lirong Chen, Xiaodong Teng, Yongfu Zhao, Guangzhi Wang, Junhong Xiao, , Tiannan Guo

This paper develops a deep learning method using DIA tensor for phenotype prediction from mass spectrometry data, achieving high accuracy in cancer classification.

bioRxiv · Mar 5, 2020 · PreprintBioinformatics